The Laboratory Investigation of Stress Factors (LIFE) has developed a long-standing expertise in metabolism, molecular biology and physiology of the yeast Saccharomyces cerevisiae. At LIFE, we are currently working on the response of S. cerevisiae to stress conditions. We have focused our interest on the mechanism by which yeasts acquire tolerance to oxidative stress, which has been linked to diseases, such as cancer, Alzheimer disease and Amyotrophic Lateral Sclerosis, and to the aging process. Because of the universal response of the stress, further insight into the response of S. cerevisiae will improve our understanding of defense mechanisms from microorganisms to man and, consequently, the necessary foundation for practical applications.
The project “Aging and oxidative stress as modulators of proteotoxicity in neurodegenerative diseases”, coordinated by Prof. Elis Eleutherio, is contemplated by the 2018 edition of the Scientists of Our State Program, State Funding Agency of Rio de Janeiro (FAPERJ).
The work of the postdoc Aline Brasil, from LIFE, "An analysis of bimolecular fluorescently-tagged wild type and mutant Sod1 heterodimers linked to Amyotrophic lateral sclerosis" was one among 12 selected for oral presentation at the SBBq-Conesul Young Scientist Symposium 2018.
MAIN PUBLICATIONS 2018
• The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1
DISCOVER WHAT WENT ON AT
The workshop “Protein misfolding: crossroads between biology, cancer and neurodegeneration”, May 20-21, 2019,
Rio de Janeiro, Brazil
Thanks for a great #Protein Misfolding 2019!