OXIDATIVE STRESS AND AGEING DISEASES

Effect of oxidative stress on longevity and on the molecular mechanisms of ageing-diseases, such as cancer, Amyotrophic Lateral Sclerosis and Alzheimer and Parkinson diseases.

ANTIOXIDANTS

Screening for new biologically active compounds (natural or synthetic) for protection against oxidative stress and ageing-diseases using
yeast cell-based assays.

OXIDATIVE STRESS RESPONSE

Effect of glutathione, superoxide dismutase and catalase on adaptation to peroxide and superoxide  stresses; effect of those antioxidants on the protection against mutagenesis, lipid and protein oxidation.

NOVEL FUNCTIONS AND APPLICATIONS OF TREHALOSE

Trehalose biosynthesis as a target for the treatment of infectious diseases caused by organisms whose infectivity and survival on host depends on trehalose.

Intermediates in trehalose biosynthesis  and  their involvement with hexokinase 2 inhibition, catabolic repression and Warburg effect.

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THE MOLECULAR BASIS OF DESICCATION TOLERANCE

Oxidative stress and its effects during dehydration; the importance of antioxidants on desiccation tolerance.

Trehalose as a protective additive to prevent a dehydrate skin condition.

HEAVY METALS

Molecular mechanisms of cadmium detoxification

Development of a microbial biosensor based on yeast  for detection and evaluation of cadmium toxicity.

BIOETHANOL

Genetic improvement of yeast  for bioenergy and biofuels.

Metabolic engineering of Saccharomyces cerevisiae for xylose fermentation.

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Department of Biochemistry
Institute of Chemistry

(UFRJ) Federal University of Rio de Janeiro

Av. Athos da Silveira Ramos, 149

CT - Bl A - sala 547

ZIP CODE 21941-909

Rio de Janeiro - RJ

Brazil

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