OXIDATIVE STRESS AND AGEING DISEASES
Effect of oxidative stress on longevity and on the molecular mechanisms of ageing-diseases, such as cancer, Amyotrophic Lateral Sclerosis and Alzheimer and Parkinson diseases.
ANTIOXIDANTS
Screening for new biologically active compounds (natural or synthetic) for protection against oxidative stress and ageing-diseases using
yeast cell-based assays.
OXIDATIVE STRESS RESPONSE
Effect of glutathione, superoxide dismutase and catalase on adaptation to peroxide and superoxide stresses; effect of those antioxidants on the protection against mutagenesis, lipid and protein oxidation.
NOVEL FUNCTIONS AND APPLICATIONS OF TREHALOSE
Trehalose biosynthesis as a target for the treatment of infectious diseases caused by organisms whose infectivity and survival on host depends on trehalose.
Intermediates in trehalose biosynthesis and their involvement with hexokinase 2 inhibition, catabolic repression and Warburg effect.
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THE MOLECULAR BASIS OF DESICCATION TOLERANCE
Oxidative stress and its effects during dehydration; the importance of antioxidants on desiccation tolerance.
Trehalose as a protective additive to prevent a dehydrate skin condition.
HEAVY METALS
Molecular mechanisms of cadmium detoxification
Development of a microbial biosensor based on yeast for detection and evaluation of cadmium toxicity.
BIOETHANOL
Genetic improvement of yeast for bioenergy and biofuels.
Metabolic engineering of Saccharomyces cerevisiae for xylose fermentation.
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